Tie (or buy) big uglies in #2. I have a variety of color combinations, mostly involving marabou or a lot of webby hackle. Black/purple works very well at first light. Olive, yellow/white, purple/white, Chartreuse/green, orange/red. Include some "flash" material.
Obviously, these are attractor/irritant patterns. Tie weight into some if you need to get a little deeper. Are you going to use a sink-tip? Royal Wulff has one that really works great because it has a continuous taper and doesn't "hinge" the way other s/t lines tend to do.