Marty, I would say Acklins is out. Eleuthera might fit the bill, or the Abacos. I don't know much about the Abacos, but certainly know Eleuthera. Long Island might be a possibility too. They have some nice resorts up north that your girlfriend would probably like.
What do you mean by mixed use? A beach to go to? Lots of action and night life?
And "ability to wade nearby" -- do you mean within walking distance, or within a short drive.
And lastly, "not totally isolated from other lodges/resorts"--do you mean you want them next door or within walking distance?
Cattaraugus Creek Outfitters
God does not deduct from man's alloted time the hours spent fishing.