Just to add my unsolicited $0.02...
I dislike flouro in general because of abrasion sensitivity - you have to frequently run it between your fingers and aggressively cut and replace any rough patches. This becomes a chore when fishing rough terrain such as jetties, rock piles etc.
For that reason I have limited my use of flouro to times when I am targeting line shy tunoids, most often false albacore.
Having said that, I find it strange that I have never run into the knot problems that so many attribute to flouro. I have had flyshop dudes tell me flat out "You CAN NOT" use blood knots, clinch knots etc. Never being one to listen to the voice of authority, I ignored them and stick to the knots I learned when I was 10.
I ONLY use blood knots to attach flouro tippet to mono leader and I only use improved clinch to attach flies. Now before I go on, let me just clarify that this choice is more personal preference and not meant to endorse specific knots. Your milage will almost certainly vary.
Nevertheless, I have hooked dozens of fast moving tunoids and landed a fair percentage of those and NEVER ONCE has either a blood knot or clinch knot in flouro failed me. This is saying alot as I fish mostly from shore and use mostly 12 lb tippet. That makes for a prolonged tug o' war with lots of extreme exceleration. In other words, a really good test for the knots.
On those few occasions when I break one off, invariably it is either an abraded patch in the flouro or a wind knot.
As someone else mentioned, tying technique is critical. A poorly tied knot will fail first, no matter what kind it is.